Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish
نویسندگان
چکیده
منابع مشابه
Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish.
Cellular metabolism provides various sources of hydrogen peroxide (H2O2) in different organelles and compartments. The suitability of H2O2 as an intracellular signaling molecule therefore also depends on its ability to pass cellular membranes. The propensity of the membranous boundary of the endoplasmic reticulum (ER) to let pass H2O2 has been discussed controversially. In this essay, we challe...
متن کاملProtein Translocation Across the Endoplasmic Reticulum Membrane
Proteins to be secreted from eukaryotic cells are delivered to the extracellular space after trafficking through a secretory pathway composed of several complex intracellular compartments. Secretory proteins are first translocated from the cytosol into the endoplasmic reticulum (ER), after which they travel by vesicular trafficking via various intermediate destinations en route to the plasma me...
متن کاملRetrograde transport of toxins across the endoplasmic reticulum membrane.
Several protein toxins, including the A chain of the plant protein ricin (RTA), enter mammalian cells by endocytosis and catalytically modify cellular components to disrupt essential cellular processes. In the case of ricin, the process inhibited is protein synthesis. In order to reach their cytosolic substrates, several toxins undergo retrograde transport to the ER (endoplasmic reticulum) befo...
متن کاملMechanism of protein translocation across the endoplasmic reticulum membrane.
MECHANISM OF TARGETING............................................................................................ 501 Signal Recognition Particle ...................................................................................... 502 Signal Sequences ............................................................. ............................. ..... ....... 507 SRP Receptor ............ . . .....
متن کاملAn ATP-binding membrane protein is required for protein translocation across the endoplasmic reticulum membrane.
The role of nucleotides in providing energy for polypeptide transfer across the endoplasmic reticulum (ER) membrane is still unknown. To address this question, we treated ER-derived mammalian microsomal vesicles with a photoactivatable analogue of ATP, 8-N3ATP. This treatment resulted in a progressive inhibition of translocation activity. Approximately 20 microsomal membrane proteins were label...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Free Radical Biology and Medicine
سال: 2016
ISSN: 0891-5849
DOI: 10.1016/j.freeradbiomed.2016.02.030